Fundamentals of Spray-Dried Dispersion Technology

April 7, 2016 - 9:30am

REGISTER TODAY

April 7, 2016 | 12:30pm EDT/9:30am PDT

 

About the Webinar:

Current estimates indicate that more than 70% of new chemical entities require solubilization technology to achieve efficacious plasma exposure. Amorphous solid dispersion technology is a leading approach to improve solubility and dissolution rate of these insoluble compounds by providing a supersaturated concentration of drug in the gastrointestinal environment, which often translates to rapid absorption and improved bioavailability. Amorphous solid dispersions are typically prepared by using hot-melt extrusion or spray drying processes. This webinar will focus on the fundamentals of formulating and processing of spray-dried dispersions, including stability assessment, in-vitro performance, and downstream manufacturability.

 
Learning Objectives:
  •   Discuss key parameters that indicate amorphous dispersions and specifically spray dry dispersions as an optimal enabling approach.
  •   Review how the spray drying process can be scaled from tens of milligrams to metric tons.
  •   Explain best practices for formulation screening and evaluation of stability, performance, and manufacturability of spray-dried dispersions.
  •   Evaluate methodologies and tools for spray drying process development and scale-up through clinical supply and commercial manufacturing.
 
Moderator:

David Vodak, Ph.D., Capsugel Dosage Form Solutions

 
Speakers:
Amber Broadbent, Ph.D.

Amber Broadbent is a Director of Engineering at Bend Research. She leads interdisciplinary teams of scientists and engineers to develop and manufacture novel pharmaceutical formulations. Her primary areas of expertise include process development, scale-up, and de-risking of spray dried-dispersions (SDDs) and osmotic controlled-release tablets. Dr. Broadbent has been with Bend Research since 2011. She graduated with a Ph.D. in engineering, with a chemical engineering focus, from Montana State University.

 
Aaron Stewart, M.S.

Aaron Stewart is a Research Scientist at Bend Research. He works on internal research and development initiatives to better understand the fundamentals of formulation and in vitro characterization. His primary areas of expertise are in amorphous dispersion formulation development including drug speciation, absorption, performance, and stability. Aaron has been with Bend Research since 2011. He graduated with a M.S in chemistry, with a materials science focus, from the University of Oregon. 

 

Topics: 
Bioavailability Enhancement