Bioavailability Enhancement Webinar Series: Lipid / Liquid Based Formulation Scale-up and Manufacturing

June 18, 2014 - 8:00am


An overwhelming number of chemical entities in development fall under Biopharmaceutical Classification System IIa and IIb which, if unattended, can inhibit a candidate compound from being developed or lead to sub-optimized / variable oral absorption.  Lipid based formulations have an unparalleled ability to address solubility, by increasing and sustaining drug solubilization in the intestinal lumen, through both dispersion and digestion, into a myriad of vesicles that harness physiological processes. Resulting lipid based formulations - Lipid Formulation Classification System (LFCS) Type I (oily solutions), Types II-IIIA (self-emulsifying) or Types IIIB-IV (self-(micro)emulsifying) - can be optimally filled and sealed into hard or soft capsules. The technology, equipment and processes to fill liquids, semi-solids or solids across a wide rheological spectrum from pilot scales to clinical and commercial scales can accelerate and de-risk the pharmaceutical development pathway. This webinar aims at highlighting the key considerations and steps required to successfully take unique lipid / liquid –based formulations from feasibility to commercial manufacture. Representative case studies are presented.

Presented by Eduardo Jule and Stephen Brown

View the presentation by clicking the play button in the video below.

Bioavailability Enhancement