Performance of Gelatin Capsules and the Next Generation of HPMC Capsules

December 10, 2015 - 10:00am

Join Capsugel for a webinar on December 10th at 1pmET | 10amPT 

Register today!


  • Matt Richardson, Ph.D., Manager, Pharmaceutical Business Development, Capsugel
  • Michael Morgen, Ph.D., Senior Principal Scientist, Capsugel Dosage Form Solutions


Two-piece hard shell capsules made from hydroxypropyl methylcellulose (HPMC) have typically been used as an alternative to conventional gelatin capsules for oral drug delivery for ingredients that are chemically incompatible with gelatin, hygroscopic or sensitive to moisture. A relatively new HPMC polymer capsule without secondary gelling agents developed through a thermo-gelation process (Vcaps® Plus), has shown dissolution profiles similar to hard gelatin capsules – including pH and ionic independence – for a number of APIs (active pharmaceutical ingredients). 

Though HPMC capsules are used in marketed drugs, there are few comparisons of the in vivo performance between gelatin and HPMC available in literature. In this webinar, we present the results of in vitro dissolution and an in vivo bioequivalence study comparing the performance of the identical formulation of three different drugs in Vcaps® Plus capsules to HGC. In addition, the circumstances under which the same API and formulation contained in HG and Vcaps® Plus can be expected to provide equivalent performance will be discussed.

In this webinar, you will learn:

  • Characteristics of the next generation of HPMC capsules 
  • The in vitro and in vivo performance comparison of HGC vs. HPMC for several drugs
  • Mechanistic situations that can influence relative performance of HCG vs. HPMC for specific delivery application


Bioavailability Enhancement