Solubilization by Extrusion: Formulation Selection and Process Development

March 15, 2012 - 10:00am

Presented by Trevor Wigle, P.E., Vice President

 

Hot-melt extrusion is a processing technique that is being widely implemented for the solubilization of BCS-class 2 or 4 pharmaceuticals.  Relative to other processing techniques, it can serve as a low-cost, continuous option that is scalable and commercially viable.  To achieve those final goals, a robust formulation and process needs to be defined early in development.  A structured approach for selecting a formulation and process will be reviewed, as well as a fundamental approach to defining an operating space to promote a robust, scalable process.