March 15 Webinar: Solubilization by Extrusion: Formulation Selection and Process Development

March 15, 2012 - 10:00am (Pacific Time)

Hot-melt extrusion is a processing technique that is being widely implemented for the solubilization of BCS-class 2 or 4 pharmaceuticals.  Relative to other processing techniques, it can serve as a low-cost, continuous option that is scalable and commercially viable.  To achieve those final goals, a robust formulation and process needs to be defined early in development.  A structured approach for selecting a formulation and process will be reviewed, as well as a fundamental approach to defining an operating space to promote a robust, scalable process.

Presenter: Trevor Wigle, P.E., Vice President

Trevor Wigle, P.E.

Mr. Wigle, Vice President, is responsible for all aspects of engineering and facilities, including strategic leadership and planning, financial management, and engineering excellence. He has led multidisciplinary teams to design, build, and maintain equipment and facilities used to make pharmaceutical products, particularly those based on extrusion platforms.  His expertise includes managing technically complex, multi-national engineering products, including technology and product development and commercialization.  Mr. Wigle holds a bachelor’s degree in mechanical engineering from Santa Clara University and a master’s degree in mechanical engineering from Stanford University.  He is a licensed Professional Engineer in Oregon and has two publications.  He has worked at Bend Research since 2003.