Spray-Dried NanoAdsorbate (SDNA) Technology
Spray-Dried NanoAdsorbate Technology, or SDNA, consists of a solid amorphous dispersion adsorbed to the surface of a high surface-area insoluble material, such as fumed silica and silicon dioxide. This approach greatly increases the surface area of the dispersion relative to normal dispersion particles, leading to rapid dissolution of the drug, resulting in improved bioavailability relative to crystalline drug.
Scanning Electron Microscopy (SEM) analysis of SDNA formulations:
Illustration and Transmission Electron Microscopy (TEM) analysis of SDNA formulations containing various amounts of drug:
SDNAs are made using a spray-drying process. During the process, the drug and polymer are dissolved in a solvent, while the high surface-area insoluble material is suspended in the spray solution. The suspension is then spray-dried to form solid particles containing the SDNAs. The SDNAs can then be incorporated into solid dosage forms, such as tablets and capsules, for immediate- or modified-release, depending on the desired therapeutic profile.
SDNAs have advantages for formulating mixtures of drugs, mixtures of drug and surfactants, liquid/lipid formulations, and semi-solid formulations. Other advantages of SDNAs include
- Improved physical stability relative to pure amorphous formulations
- Stabilization of drugs that rapidly crystallize
- Increased bioavailability relative to crystalline drug or large amorphous particles
- Increased dissolution rate of drug relative to crystalline drug
- For liquid and semi-solid drug formulations, SDNAs are amenable to forming solid dosage forms and combination products
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