Vaccine and Biotherapeutic Formulation Development and Manufacture Using Spray-Drying

July 10, 2013 - 8:00am

Overview:

The pharmaceutical industry has been increasingly focused on the formulation of vaccines and biotherapeutics, especially in regard to manufacturing by spray-drying. Spray-drying is being pursued as an alternative to lyophilization for biotherapeutic formulations, due to the inherent robustness of the technology, the minimal amount of drug product required for formulation and process development, and the gentle processing nature of spray-drying biopharmaceuticals. Specific interest in this area has been focused on solid-state stabilization for compound storage, high-concentration protein processing, and parenteral or inhalation delivery.

This webinar will discuss approaches used at Bend Research to design, assay, and manufacture spray-dried powder formulations containing proteins and nucleic acids. Case studies will be presented that highlight work we have performed in this area. Formulation design and spray-drying process parameters will be discussed with a focus on target product specifications. The utility of solid-state characterization tools such as differential scanning calorimetry, vapor sorption, and x-ray diffraction will be presented as well.

Speakers: Devon DuBose, P.E. and Jeff Breit, Ph.D.

Topics: 
Biotherapeutics / Bioprocessing