Process Development and Scale-Up
BRI-C Instruments, Equipment, and Activity Slideshow
In addition to process-modeling work, process
development and scale-up are necessary for a new technology to
be applied beyond the laboratory scale. Key members of the Bend Research
process development group include Lori Ray, Trevor Wigle, Dan Dobry, and Dana Settell. The main goals of this group include the following:
- To work with the fundamental science group to reduce new technologies to practice
- To ready these new technologies for transfer to the BRPPD cGMP facility
- To follow through to scale-up of commercial processes.
Process development work has focused on technologies such as spray-drying,
melt-spray-congealing, fluid-bed drying and coating, and other pharmaceutical manufacturing
processes.
An understanding of the chemistry and physical science behind a technology
combined with a knowledge of applied engineering have enabled this group to
successfully scale up several new technologies for
pharmaceutical products. This wider knowledge is gained from working
closely with colleagues who work in the fundamental
science, applied technology, and process modeling areas, and
colleagues at BRPPD and other manufacturing sites. The slideshow link
shows an overall view of various projects and activities at Bend
Research’s pilot facility.
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