Collaborative Transformation of Biotherapeutics

The transformation of biotherapeutics will require a new level of collaboration among a wide variety of disciplines encompassing biology, engineering, advanced process control, signal processing, modeling, molecular biology, and higher mathematics. By leveraging knowledge from each of these disciplines, the design, optimization, and control of biotherapeutic production can be revolutionized. Since the characteristics of the product depend directly on the behavior, or state, of the cell population, quantifying and understanding the “cell state” is paramount to achieving process improvements, meeting quality-by-design (QBD) requirements, and shortening development timelines.

Topics: 
Biotherapeutics / Bioprocessing