Bioprocess Design and Operation: Enhanced Bioreactor Observability and Process Guidance

February 10, 2015 - 11:00am

Dr. Clint Pepper and Dr. Jeffrey Breit, both of Bend Research,present this webinar. Dr. David Lyon of Bend Research is the moderator.

The presenters at Bend Research, a division of Capsugel Dosage Form Solutions, describe how real time data generation and visualization tools are being used to monitor bioreactor processes in order to enhance cell line and process understanding for research scientists.

Biopharmaceutical companies are continually striving to fundamentally understanding of the cells state within their bioreactors and the impact of process conditions on the cell’s ability to deliver target product quality. While implementation of on-line process analytical technology (PAT) tools like dielectric and Raman spectroscopy are helping to provide insight, integrating data produced by these techniques with off-line measurements such as cell density, viability, and titer remains an elusive goal.

Bend Research, in collaboration with Pfizer and other major biopharmaceutical companies, continues to advance its Modular Automated Sampling Technology (MASTTM) and automated data retrieval and analysis platforms. The ultimate goal of these systems is to enable improved bioreactor productivity and efficiency through effective and real time data generation and management. The overall solution to the end user incorporates aseptically collected bioreactor samples delivered to multiple analytical devices and a graphical user interface (GUI) for real-time data analysis and predictive model development. Early studies with the MAST sample delivery system, coupled with our data-processing software, indicate better system ‘observability’ and real-time process understanding for the end user, thus setting the stage for optimized process control systems

The presenters discuss how Bend Research has created an integrated lab environment, that capitalizes on the MAST platform, to collect high density data sets for on-line analysis and predictive model generation. From this new level of insight into the bioreactor, scientists can obtain enhanced data-driven guidance for key activities, like enhanced process understanding and optimized process operation. With this new technology, the bioprocess industry can make major advances toward innovative real-time testing, predictive control, and overall enhanced bioprocess design and operation.

Biotherapeutics / Bioprocessing