Hot-Melt Extrusion Fundamentals

October 6, 2015 - 8:00am

Processing of Amorphous Solid Dispersions for Poorly Soluble Drugs

An estimated 60 percent of compounds in early development have poor solubility due to low solubility and dissolution rates (DCS IIa and IIb). Hot-melt extrusion (HME) of amorphous solid dispersions is one approach Bend Research, a division of Capsugel Dosage Form Solutions, uses to address APIs with limited bioavailability. By using small scale screening techniques and an integrated process and formulation approach, Bend Research is able to rapidly develop a progressable drug intermediate and dosage form for preclinical and clinical manufacture. These approaches balance the target absorption profile, manufacturability, physical and chemical stability, and API availability.

In this webinar

Scientists Charlie McLaughlin and Scott Bone from Bend Research will provide insight into HME fundamentals, including solid dispersion formulation selection. Strategies and case studies for solid dispersion formulation selection will be reviewed, as will definitions of the HME process operating space.

Presenters

Charlie McLaughlin, Engineering Technical Group Lead

 

 

 

Scott Bone, Chemistry Technical Group Lead

 

 

 

View the presentation by clicking the play button in the video below.

 

Topics: 
Bioavailability Enhancement