Formulation and In Vitro Analysis of a Spray-Dried Albuterol Sulfate and Ipratropium Bromide Combination Inhalation Powder

The goal of this work was to determine the feasibility of formulating and testing a spray-dried combination powder using pharmaceutical compounds typically used to treat asthma and chronic obstructive pulmonary disease (COPD).  Specifically, we describe the manufacturing approach and in vitro test for a spray-dried ipratropium bromide/albuterol sulfate dry-powder combination formulation that contained dextran as an excipient.

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