Pharmacokinetic and Stability Analysis of an Inhalable Formulation of Camptothecin for the Treatment of Lung Cancer

This work focused on creating an inhalable dry-powder camptothecin (CPT) formulation that could be tested in vivo and potentially developed into a lung-cancer therapeutic. CPT and analogs of CPT have been shown to be effective in treating lung cancers, but the physical properties of CPT have made it difficult to formulate into a deliverable therapeutic. Due to its extremely fast rate of crystallization, CPT has very poor aqueous solubility, which has limited its therapeutic potential and its use in the clinic.

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