Modified & Targeted Release

Small-Scale Manufacture of Modified-Release Coated Beads For Preclinical Drug Discovery Research

Modified-release technologies are used early in discovery to

• enable mechanism/target testing of molecules with non-ideal pharmacokinetics,

• reduce dosing frequency,

• reduce stress to animals, and

• enable target validation requiring prolonged plasma levels.

 

The objective was to develop a “micro-scale” fluid-bed system that met the following criteria to enable these discovery studies:

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