Bioavailability Enhancement

Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions

Date: 
September 15, 2011
Short Description: 
This study explored the utility of topically applied polymeric nanoparticle suspensions to target delivery of poorly water-soluble drugs to hair follicles. Several formulations of amorphous drug/polymer nanoparticles were prepared from ethyl cellulose and UK-157,147 (systematic name (3S,4R)-[6-(3-hydroxyphenyl)sulfonyl]-2,2,3-trimethyl-4-(2-methyl-3-oxo-2,3-dihydropyridazin-6-yloxy)-3-chromanol), a potassium channel opener, using sodium glycocholate (NaGC) as a surface stabilizer.

 

Morgen, M., G.W. Lu, D. Du, R. Stehle, F. Lembke, J. Cervantes, S. Ciotti, R. Haskell, D. Smithey, K. Haley, and C. Fan, “Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions,” Int. J. Pharm., 416:1(2011)314-322.

 

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