Bioavailability Enhancement

Nanoparticles for Improved Local Retention after Intra-Articular Injection into the Knee Joint

Date: 
September 21, 2012
Short Description: 
The purpose of this paper is to evaluate using cationic polymeric nanoparticles that interact with hyaluronate to form ionically cross-linked hydrogels to increase the intra-articular retention time of osteoarthritis drugs in the synovial cavity. This study demonstrates the feasibility of using cationic polymeric nanoparticles to increase the retention of therapeutic agents in articular joints for indications such as osteoarthritis.

 

Morgen, M., D. Tung, B. Boras, W. Miller, A.-M. Malfait, and M. Tortorella, “Nanoparticles for Improved Local Retention after Intra-Articular Injection into the Knee Joint,” Pharm. Res., 30:1(2013)257-268. 

 

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