Bioavailability Enhancement

Solid Nanocrystalline Dispersions of Ziprasidone with Enhanced Bioavailability in the Fasted State

Date: 
October 16, 2012
Short Description: 
Reducing the absorption difference between fed and fasted states is an important goal in the development of pharmaceutical dosage forms. The goal of this work was to develop and characterize a solid nanocrystalline dispersion (SNCD) to improve the oral absorption of ziprasidone in the fasted state, thereby reducing the food effect observed for the commercial formulation.

 

Thombre, A.G., W.B. Caldwell, D.T. Friesen, S.B. McCray, and S.C. Sutton, "Solid Nanocrystalline Dispersions of Ziprasidone with Enhanced Bioavailability in the Fasted State," Mol. Pharm., 9:12(2012)3526-3534.

 

 

Continue Reading

Pages

Subscribe to RSS - Bioavailability Enhancement