Biotherapeutics / Bioprocessing

Spray-Dry Manufacture of Vaccine Formulations

October 1, 2013
Short Description: 
Development of vaccines and immunotherapeutics has expanded rapidly due to technological advances in the fields of molecular biology and bioprocess engineering, as well as a smoothing of management and material logistics worldwide. Expression platforms and novel cell lines have enabled creation of increasingly complex vaccines. The advancement of vaccine formulation development is also capitalizing on new advances in manufacturing that use model-based methodologies gleaned from physiochemical principles, process analytical tools, and systematic approaches to problem solving. Herein we highlight recent advancements in spray-dried vaccine formulation, which has been successfully applied to develop stable and effective formulations across a spectrum of vaccine types.


Breit, J.F., and D.B. DuBose, “Spray-Dry Manufacture of Vaccine Formulations,” Bioprocess Int., 11:S9(2013)32-41.


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