Biotherapeutics / Bioprocessing

Solid State Formulation of Therapeutic Antibodies Using Spray Drying for High Concentration Reconstitution

The development of high concentration antibody solutions is being explored for use both in material logistics and storage as well as for clinical application. The design of a robust and high performing solid state formulation platform using a spray dry manufacturing process requires the optimization of spray drying attributes (i.e. nozzle selection and flow rates) and selection of appropriate formulation/excipient components including low molecular weight sugars, buffers and surfactants.

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