Amorphous Solid Dispersion Using Hot-Melt Extrusion

Hot-melt extrusion is a technique for manufacturing amorphous solid dispersions, where-in the drug substance is melted or dissolved within an amorphous dispersion polymer and mixed to form a new miscible form of the drug substance. Bend Research has more than a decade of experience in formulation and process development using twin-screw extruders, and has been involved in multiple process transfers and scale-ups, including an active commercial process that utilizes a 50 mm extruder. Furthermore, our experience with amorphous solid dispersions can be leveraged in further formulating solid dosage forms for oral delivery, whether the project goals are for immediate- or controlled-release forms.

Bioavailability Enhancement