Bioavailability Enhancement

50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Date: 
June 1, 2016
Short Description: 
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of Lipinski's ‘rule-of-five’ chemical space. Advantages in permeability, efflux and presystemic metabolism are evident; however, the primary benefit is in increases in dissolution and apparent intestinal solubility for lipophilic, poorly water soluble drugs. - See more at: http://www.bendresearch.com/50-years-of-oral-lipid-based-formulations#sthash.zgkBAYQg.dpuf

Lipid based formulations (LBF) provide well proven opportunities to enhance the oral absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of Lipinski's ‘rule-of-five’ chemical space. Advantages in permeability, efflux and presystemic metabolism are evident; however, the primary benefit is in increases in dissolution and apparent intestinal solubility for lipophilic, poorly water soluble drugs.

Continue Reading

Pages

Subscribe to RSS - Bioavailability Enhancement