Bioavailability Enhancement

Predictive Models for Advancing Amorphous Dispersions of Poorly-Bioavailable Compounds from Drug Discovery to Commercial Product

March 20, 2013 - 8:40am
Short Description: 
This presentation will focus on predictive methodologies covering performance, stability and manufacturability of amorphous solid dispersions.


A significant fraction of active pharmaceutical ingredients (APIs) currently being developed by the pharmaceutical industry have low aqueous solubility and require enabling formulations to achieve acceptable oral absorption. Amorphous solid dispersions—prepared by spray-drying, hot-melt extrusion or precipitation—are often enabling formulations for such compounds.

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