Biotherapeutics / Bioprocessing

A Novel Approach For Using Dielectric Spectroscopy To Predict Viable Cell Volume (VCV) in Early Process Development

Date: 
January 11, 2014
Short Description: 
Online monitoring of viable cell volume (VCV) is essential to the development, monitoring, and control of bioprocesses. This work demonstrates the possible feasibility of quantifying the shape of the beta dispersion, determined from frequency-scanning data, for enhanced measurement of VCV in mammalian cell cultures by applying a novel shape-characterization technique. In addition, this work demonstrates the utility of using changes in the shape of the beta dispersion to quantify cell health.

 

Downey, B.J., L.J. Graham, J.F. Breit, and N.K. Glutting, “A Novel Approach For Using Dielectric Spectroscopy To Predict Viable Cell Volume (VCV) in Early Process Development,” Biotechnol. Prog., doi: 10.1002/btpr.1845.

 

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